{"id":238,"date":"2021-02-08T07:20:31","date_gmt":"2021-02-08T07:20:31","guid":{"rendered":"https:\/\/www.summitforstemcell.org\/?page_id=238"},"modified":"2021-03-01T16:32:38","modified_gmt":"2021-03-01T16:32:38","slug":"notable-cell-replacement-therapies","status":"publish","type":"page","link":"https:\/\/www.summitforstemcell.org\/notable-cell-replacement-therapies\/","title":{"rendered":"Notable Stem Cell-based  Therapies Around the World for Parkinson&#8217;s disease"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"238\" class=\"elementor elementor-238\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6c8ad0f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6c8ad0f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-852e762\" data-id=\"852e762\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1a0a07e elementor-widget elementor-widget-text-editor\" data-id=\"1a0a07e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em>This page provides information about other notable regenerative medicine (stem cell) research projects and clinical trials working on a stem cell-based dopamine neuron replacement therapy for Parkinson&#8217;s disease primarily.<\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2d9f036 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2d9f036\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a4e0472\" data-id=\"a4e0472\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9aa9582 elementor-widget elementor-widget-image\" data-id=\"9aa9582\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"780\" height=\"231\" src=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Jason-at-scope08.2016-1024x303.jpg\" class=\"attachment-large size-large wp-image-975\" alt=\"\" srcset=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Jason-at-scope08.2016-1024x303.jpg 1024w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Jason-at-scope08.2016-300x89.jpg 300w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Jason-at-scope08.2016-768x227.jpg 768w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Jason-at-scope08.2016-1536x454.jpg 1536w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Jason-at-scope08.2016-2048x606.jpg 2048w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6b239b9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6b239b9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b5edc42\" data-id=\"b5edc42\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-855d350 elementor-widget elementor-widget-text-editor\" data-id=\"855d350\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">Stem cell-based replacement therapy is moving forward in several groups around the world.<\/span><\/p><p>It&#8217;s important to realize these important facts about each of the projects:<\/p><ul><li>Dopamine neurons are transplanted for all of these therapies.<\/li><li>No undifferentiated stem cells are transplanted.\u00a0<\/li><li>Each of the projects uses different sources of <em>pluripotent stem cells<\/em>* (see below).<\/li><li>All are working with the regulatory agency within their country of origin. (<em>e.g.<\/em> The FDA in the U.S.)<\/li><\/ul><p><em>*Pluripotent stem cells<\/em> are capable of becoming all sorts of cell types.\u00a0 Pluripotent stem cells are not transplanted until <span style=\"text-decoration: underline;\"><em>after<\/em><\/span> they are differentiated (developed) into dopamine-producing neurons in the lab.\u00a0 See below&#8230;<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9f1eb8c elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9f1eb8c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-00d79f3\" data-id=\"00d79f3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b15b149 elementor-widget elementor-widget-text-editor\" data-id=\"b15b149\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><style type=\"text\/css\">\n.tg  {border-collapse:collapse;border-spacing:0;}<br \/>.tg td{border-color:black;border-style:solid;border-width:1px;font-family:Arial, sans-serif;font-size:14px;<br \/>  overflow:hidden;padding:10px 5px;word-break:normal;}<br \/>.tg th{border-color:black;border-style:solid;border-width:1px;font-family:Arial, sans-serif;font-size:14px;<br \/>  font-weight:normal;overflow:hidden;padding:10px 5px;word-break:normal;}<br \/>.tg .tg-c3ow{border-color:inherit;text-align:center;vertical-align:top}<br \/>.tg .tg-84w4{background-color:#6b983a;border-color:inherit;font-weight:bold;text-align:center;vertical-align:top}<br \/><\/style><\/p><table class=\"tg\"><thead><tr><th class=\"tg-84w4\" style=\"text-align: center;\">COUNTRY<\/th><th class=\"tg-84w4\" style=\"text-align: center;\">PRINCIPAL<br \/>INVESTI-GATOR<\/th><th class=\"tg-84w4\" style=\"text-align: center;\">STEM CELL<br \/>TYPE (SOURCE)<\/th><th class=\"tg-84w4\" style=\"text-align: center;\">CLINICAL<br \/>TRIAL<br \/>STATUS<\/th><th class=\"tg-84w4\" style=\"text-align: center;\">CELLS<br \/>MATCHED TO THE <br \/>PATIENT?<\/th><\/tr><\/thead><tbody><tr><td class=\"tg-c3ow\" style=\"text-align: center;\">Sweden and<br \/>U.K<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">Malin Parmar and<br \/>Roger Barker<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">Pluripotent <br \/>embryonic stem cells<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">Undeter-mined<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">NO<\/td><\/tr><tr><td class=\"tg-c3ow\" style=\"text-align: center;\">Japan<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">Jun Takahashi<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">Induced<br \/>Pluripotent stem cells<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">Two patients<br \/>trans-planted 2018-current<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">NO<\/td><\/tr><tr><td class=\"tg-c3ow\" style=\"text-align: center;\">USA, (New York)<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\"><a href=\"https:\/\/apnews.com\/press-release\/pr-newswire\/science-business-technology-stem-cell-research-products-and-services-e5f17cd39cc3aca3453236f108352ebf\"><span style=\"text-decoration: underline;\"><strong>BlueRock Thera-peutics<\/strong><\/span><\/a> \/ Lorenz Studer<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">Pluripotent <br \/>embryonic stem cells<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">01\/07\/21 Received FDA approval to begin clinical trials &#8211; now recruiting<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">NO<\/td><\/tr><tr><td class=\"tg-c3ow\" style=\"text-align: center;\">USA,<br \/>(San Diego)<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\"><a href=\"https:\/\/www.aspenneuroscience.com\/contact-us-1\"><strong>Aspen Neuro-<span style=\"text-decoration: underline;\">science, Inc.<\/span><\/strong><\/a> \/ Jeanne Loring<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">Induced<br \/>Pluripotent stem cells<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">Planned for 2022<\/td><td class=\"tg-c3ow\" style=\"text-align: center;\">YES<\/td><\/tr><\/tbody><\/table>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f8a0cd elementor-widget elementor-widget-text-editor\" data-id=\"3f8a0cd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Aspen Neuroscience with Drs. Jeanne Loring &amp; Andres Bratt-Leal in San Diego, CA are working with iPSC-sourced (induced pluripotent stem cell-sourced) autologous dopamine neurons. Dr. Loring is the <strong>only<\/strong> researcher who is working on an individualized, custom-line of autologous dopamine neurons for each patient. These DNA-matching dopamine neurons won&#8217;t require immunosuppression. The project is working closely with the FDA.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-66d359d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"66d359d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cc1a708\" data-id=\"cc1a708\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2cccdf0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2cccdf0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.summitforstemcell.org\/donate\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Donate <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>This page provides information about other notable regenerative medicine (stem cell) research projects and clinical trials working on a stem cell-based dopamine neuron replacement therapy for Parkinson&#8217;s disease primarily. Stem&#8230; <\/p>\n","protected":false},"author":1,"featured_media":1093,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Notable Stem Cell-based Therapies Around the World for Parkinson&#039;s disease - Summit for Stem Cell<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.summitforstemcell.org\/notable-cell-replacement-therapies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Notable Stem Cell-based Therapies Around the World for Parkinson&#039;s disease - Summit for Stem Cell\" \/>\n<meta property=\"og:description\" content=\"This page provides information about other notable regenerative medicine (stem cell) research projects and clinical trials working on a stem cell-based dopamine neuron replacement therapy for Parkinson&#8217;s disease primarily. 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