{"id":272,"date":"2021-02-08T08:51:59","date_gmt":"2021-02-08T08:51:59","guid":{"rendered":"https:\/\/www.summitforstemcell.org\/?page_id=272"},"modified":"2021-11-08T08:15:02","modified_gmt":"2021-11-08T08:15:02","slug":"cell-based-therapy-for-pd","status":"publish","type":"page","link":"https:\/\/www.summitforstemcell.org\/cell-based-therapy-for-pd\/","title":{"rendered":"Stem Cell-based  (Regenerative Medicine) Therapy for Parkinson&#8217;s disease"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"272\" class=\"elementor elementor-272\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d037064 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d037064\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-12f0cfe\" data-id=\"12f0cfe\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-db13ac3 elementor-widget elementor-widget-heading\" data-id=\"db13ac3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Autologous induced pluripotent stem cell-derived dopamine neuron replacement therapy for Parkinson's disease<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-67df6f7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"67df6f7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5f6a32b\" data-id=\"5f6a32b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b5ab1b1 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"b5ab1b1\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.summitforstemcell.org\/donate\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Donate Now<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-af7cfc8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"af7cfc8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ee403be\" data-id=\"ee403be\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-41d7a00 elementor-widget elementor-widget-text-editor\" data-id=\"41d7a00\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Why<strong> treat Parkinson&#8217;s disease with cell therapy?<\/strong><\/h4>\n<p>Parkinson&#8217;s disease is an ideal candidate for cell replacement therapy because it is caused by the loss of <strong>a single cell type in a specific part of the brain.<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fe134d9 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fe134d9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7e68840\" data-id=\"7e68840\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-30e6d8a elementor-widget elementor-widget-image\" data-id=\"30e6d8a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"421\" height=\"320\" src=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Parkinsons-disease.jpg\" class=\"attachment-full size-full wp-image-282\" alt=\"\" srcset=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Parkinsons-disease.jpg 421w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Parkinsons-disease-300x228.jpg 300w\" sizes=\"(max-width: 421px) 100vw, 421px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2a2b995\" data-id=\"2a2b995\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5bd283b elementor-widget elementor-widget-text-editor\" data-id=\"5bd283b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>Parkinson&#8217;s disease is caused by loss of dopamine neurons<\/strong><\/p><ul><li>&gt;50% of dopamine neurons are gone by diagnosis<\/li><li>Parkinson&#8217;s disease is the second most common neurological disorder<\/li><li>10 million patients worldwide<\/li><li>Drug therapy (L-DOPA) cannot treat the disease long-term.<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eed42d4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"eed42d4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eaa9db9\" data-id=\"eaa9db9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5ebf40b elementor-widget elementor-widget-heading\" data-id=\"5ebf40b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Proof of concept: Fetal tissue grafts<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9c0e465 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9c0e465\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-abaebad\" data-id=\"abaebad\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b64f5a7 elementor-widget elementor-widget-text-editor\" data-id=\"b64f5a7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>In the late 1990s and early 2000s, more than 300 people with PD were transplanted with brain tissue from 6-10 week old fetuses.<\/p><p>The results were variable, but in some cases symptoms were reversed and sustained for more than 20 years.<\/p><p>Issues related to fetal tissue transplants:<\/p><ul><li>Insufficient tissue<\/li><li>\u200bHighly variable tissue<\/li><li>\u200bCannot comprehensively analyze tissue before transplant<\/li><li>\u200bGraft-induced dyskinesias<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-20ca742\" data-id=\"20ca742\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-39d8441 elementor-widget elementor-widget-image\" data-id=\"39d8441\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"371\" height=\"409\" src=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/fetal-tissue-grafts.jpg\" class=\"attachment-full size-full wp-image-691\" alt=\"\" srcset=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/fetal-tissue-grafts.jpg 371w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/fetal-tissue-grafts-272x300.jpg 272w\" sizes=\"(max-width: 371px) 100vw, 371px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-777e3ae elementor-widget elementor-widget-text-editor\" data-id=\"777e3ae\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Freed, CR et. al. New Engl. J. of Med. 344(10), 710-719 (2001); Grealish, et. al. Cell Stem Cell 15, 653-665 (2014); Olanow CW, et. al. Ann Neurol. 54:403-414 (2003); Wen Li, et. al. PNAS 113:6544-6549 (2016)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-150012c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"150012c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d5c3fc4\" data-id=\"d5c3fc4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bd85b0f elementor-widget elementor-widget-heading\" data-id=\"bd85b0f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Induced pluripotent stem cells (iPSCs) for neuron replacement therapy<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-416c44a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"416c44a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-98c105d\" data-id=\"98c105d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ae52b2f elementor-widget elementor-widget-image\" data-id=\"ae52b2f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"342\" height=\"253\" src=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/tree.jpg\" class=\"attachment-full size-full wp-image-667\" alt=\"\" srcset=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/tree.jpg 342w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/tree-300x222.jpg 300w\" sizes=\"(max-width: 342px) 100vw, 342px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d53626a elementor-widget elementor-widget-text-editor\" data-id=\"d53626a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4 style=\"text-align: center;\">Pluripotent stem cells<\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-dce3b06\" data-id=\"dce3b06\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a9e8fe6 elementor-widget elementor-widget-text-editor\" data-id=\"a9e8fe6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>Autologous iPSC-derived dopamine neuron replacement therapy uses iPSCs<\/strong><\/p><p><strong>Advantages:<\/strong><\/p><ul><li>Can be made from patients<\/li><li>Do not require immune suppression &#8211; AUTOLOGOUS (as opposed to allogeneic)<\/li><li>Unlimited source of cells<\/li><li>Ability to differentiate into any cell type<\/li><li>Can control their fate in culture to dopamine neurons<\/li><li>Amenable to comprehensive quality control<\/li><\/ul><p>(See &#8220;Stem Cells 101&#8221; for more info on iPSCs)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b65d85 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b65d85\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-600779d\" data-id=\"600779d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-144e609 elementor-widget elementor-widget-heading\" data-id=\"144e609\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The Approach<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0139aae elementor-widget elementor-widget-image\" data-id=\"0139aae\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"691\" height=\"426\" src=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/The-Approach.png\" class=\"attachment-full size-full wp-image-673\" alt=\"\" srcset=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/The-Approach.png 691w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/The-Approach-300x185.png 300w\" sizes=\"(max-width: 691px) 100vw, 691px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c273a4 elementor-widget elementor-widget-text-editor\" data-id=\"2c273a4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li>Skin punch biopsies are taken from Parkinson\u2019s disease patients to isolate skin cells<\/li><li>Skin cells are reprogrammed to make iPSCs that are immune matched (autologous) to the patient<\/li><li>The iPSCs are differentiated into dopamine producing neurons<\/li><li>The dopamine producing neurons are transplanted back into the patient to reset the clock on Parkinson\u2019s disease<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1609f28 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1609f28\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1d58c4e\" data-id=\"1d58c4e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d4873bb elementor-widget elementor-widget-heading\" data-id=\"d4873bb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Autologous vs. Allogeneic Stem Cell Therapy<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-48973d0 elementor-widget elementor-widget-image\" data-id=\"48973d0\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"735\" height=\"264\" src=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Autologous-vs.-Allogeneic.png\" class=\"attachment-full size-full wp-image-679\" alt=\"\" srcset=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Autologous-vs.-Allogeneic.png 735w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/Autologous-vs.-Allogeneic-300x108.png 300w\" sizes=\"(max-width: 735px) 100vw, 735px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-34642e2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"34642e2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-45c60b5\" data-id=\"45c60b5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-98c7efd elementor-widget elementor-widget-heading\" data-id=\"98c7efd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">International stem cell therapies for Parkinson's Disease<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-054ad1b elementor-widget elementor-widget-image\" data-id=\"054ad1b\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"812\" height=\"497\" src=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/International-stem-cell-therapies.png\" class=\"attachment-full size-full wp-image-680\" alt=\"\" srcset=\"https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/International-stem-cell-therapies.png 812w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/International-stem-cell-therapies-300x184.png 300w, https:\/\/www.summitforstemcell.org\/wp-content\/uploads\/2021\/02\/International-stem-cell-therapies-768x470.png 768w\" sizes=\"(max-width: 812px) 100vw, 812px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bde2a0 elementor-widget elementor-widget-text-editor\" data-id=\"9bde2a0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>*Note that the Summit for Stem Cell PD Trial mentioned in the table above has been transferred to Aspen Neuroscience (see below for more info)<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-884de75 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"884de75\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e55210f\" data-id=\"e55210f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9c936be elementor-widget elementor-widget-heading\" data-id=\"9c936be\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Summit\u2019s role in the development of the autologous iPSC-derived dopamine neuron replacement therapy<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2398438 elementor-widget elementor-widget-text-editor\" data-id=\"2398438\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li class=\"font_8\">Summit was founded in 2011 as a grass roots volunteer organization comprised of patients, medical and scientific professionals and community members with a desire to raise funds for a stem cell-based solution to Parkinson\u2019s disease.<\/li><li class=\"font_8\">Summit paired with Drs Jeanne Loring and Andres Bratt-Leal, then located at the Scripps Research Institute in La Jolla, CA to develop this stem cell based therapy.\u00a0<\/li><li class=\"font_8\">Over the years, Summit raised millions of dollars to support this project.<\/li><li class=\"font_8\">As the project progressed, it became clear that in order for the project to be successful, a private sector biotech company would have to be built in order to raise the type of funds that would be necessary to bring the project from bench to bedside.\u00a0<\/li><li class=\"font_8\">In 2018, Aspen Neuroscience was created to bring the autologous iPSC-derived dopamine neuron replacement therapy to the Parkinson\u2019s patient population and now the project is on an accelerated path toward FDA-approved clinical trials.<\/li><li class=\"font_8\">Summit continues with passionate dedication to advocate for persons living with Parkinson\u2019s and other neurodegenerative diseases.\u00a0<\/li><li class=\"font_8\">We update patients about the autologous iPSC-derived dopamine neuron replacement therapy, provide financial assistance to patients who want to participate in the trial and fund evidence based regenerative medical therapies for Parkinson\u2019s and other neurodegenerative diseases.\u00a0<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ade15d elementor-align-center elementor-widget elementor-widget-button\" data-id=\"1ade15d\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.summitforstemcell.org\/donate\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Please DONATE Today<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Autologous induced pluripotent stem cell-derived dopamine neuron replacement therapy for Parkinson&#8217;s disease Donate Now Why treat Parkinson&#8217;s disease with cell therapy? Parkinson&#8217;s disease is an ideal candidate for cell replacement&#8230; <\/p>\n","protected":false},"author":1,"featured_media":1093,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Stem Cell-based (Regenerative Medicine) Therapy for Parkinson&#039;s disease<\/title>\n<meta name=\"description\" content=\"Parkinson\u2019s disease is an ideal candidate for cell replacement therapy because it is caused by the loss of a single cell type in a specific part of the brain.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.summitforstemcell.org\/cell-based-therapy-for-pd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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